Dose-related safety and immunogenicity of a trivalent baculovirus-expressed influenza-virus hemagglutinin vaccine in elderly adults.

نویسندگان

  • John J Treanor
  • Gilbert M Schiff
  • Robert B Couch
  • Thomas R Cate
  • Rebecca C Brady
  • C Mhorag Hay
  • Mark Wolff
  • Dewei She
  • Manon M J Cox
چکیده

BACKGROUND Influenza-virus hemagglutinin (HA) protein expressed in insect cells by recombinant baculovirus is a candidate influenza vaccine. METHODS In a randomized, double-blind trial conducted in 399 adults > or = 65 years of age, the efficacy of trivalent inactivated influenza vaccine (TIV) licensed for intramuscular injection was compared with that of trivalent baculovirus-expressed HA vaccine administered at doses of 15 microg, 45 microg, or 135 microg of each HA. RESULTS Compared with TIV, baculovirus-expressed HA vaccine was safe and induced better serum antibody responses to the H3 component when administered at doses of 45 microg or 135 microg of each HA. CONCLUSIONS Baculovirus-expressed HA is a safe and immunogenic influenza vaccine in elderly adults.

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عنوان ژورنال:
  • The Journal of infectious diseases

دوره 193 9  شماره 

صفحات  -

تاریخ انتشار 2006